Size：

100μl   50μl

BACKGROUND：

Paired box (PAX) proteins are a family of transcription factors that play important  and diverse roles in animal development. Nine PAX proteins (PAX1-9) have been described in humans and other mammals. They are defined by the presence of an  amino-terminal paired domain, consisting of two helix-turn-helix motifs, with DNA  binding activity. PAX proteins are classified into four structurally distinct subgroups  (I-IV) based on the absence or presence of a carboxy-terminal homeodomain and a  central octapeptide region. Subgroup I (PAX1 and 9) contains the octapeptide but  lacks the homeodomain; subgroup II (PAX2, 5, and 8) contains the octapeptide and a  truncated homeodomain; subgroup III (PAX3 and 7) contains the octapeptide and a  complete homeodomain; and subgroup IV (PAX4 and 6) contains a complete  homeodomain but lacks the octapeptide region. PAX proteins play critically  important roles in development by regulating transcriptional networks responsible for  embryonic patterning and organogenesis; a subset of PAX proteins also maintain  functional importance during postnatal development. Research studies have  implicated genetic mutations that result in aberrant expression of PAX genes in a  number of cancer subtypes (1-3), with members of subgroups II and III identified as  potential mediators of tumor progression.

SOURCE：

A synthesized peptide derived from human PAX3, corresponding to a region within the  internal amino acids.

STORAGE：

Store at -20℃ Stable far one year from the date of shipment.

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